Cellular response to endoplasmic reticulum stress: a matter of life or death.

Published

Journal Article (Review)

The proper functioning of the endoplasmic reticulum (ER) is critical for numerous aspects of cell physiology. Accordingly, all eukaryotes react rapidly to ER dysfunction through a set of adaptive pathways known collectively as the ER stress response (ESR). Normally, this suite of responses succeeds in restoring ER homeostasis. However, in metazoans, persistent or intense ER stress can also trigger programmed cell death, or apoptosis. ER stress and the apoptotic program coupled to it have been implicated in many important pathologies but the regulation and execution of ER stress-induced apoptosis in mammals remain incompletely understood. Here, we review what is known about the ESR in both yeast and mammals, and highlight recent findings on the mechanism and pathophysiological importance of ER stress-induced apoptosis.

Full Text

Duke Authors

Cited Authors

  • Boyce, M; Yuan, J

Published Date

  • March 2006

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 363 - 373

PubMed ID

  • 16397583

Pubmed Central ID

  • 16397583

International Standard Serial Number (ISSN)

  • 1350-9047

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4401817

Language

  • eng

Conference Location

  • England