Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.

Journal Article (Journal Article)

The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification.

Full Text

Duke Authors

Cited Authors

  • Long, K; Boyce, M; Lin, H; Yuan, J; Ma, D

Published Date

  • September 1, 2005

Published In

Volume / Issue

  • 15 / 17

Start / End Page

  • 3849 - 3852

PubMed ID

  • 16002288

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2005.05.120


  • eng

Conference Location

  • England