Caspases: an ancient cellular sword of Damocles.


Journal Article (Review)

Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.

Full Text

Duke Authors

Cited Authors

  • Boyce, M; Degterev, A; Yuan, J

Published Date

  • January 2004

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 29 - 37

PubMed ID

  • 14647235

Pubmed Central ID

  • 14647235

International Standard Serial Number (ISSN)

  • 1350-9047

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4401339


  • eng

Conference Location

  • England