Sustained elite suppression of replication competent HIV-1 in a patient treated with rituximab based chemotherapy.

Journal Article (Journal Article)

The mechanism of elite control of HIV-1 replication is not fully understood. While immunosuppression due to rituximab based chemotherapy has been associated with increased replication of HBV, CMV, and HIV-1, control of replication-competent HIV-1 was maintained in an elite controller/suppressor treated with a regimen that included vincristine, cyclophosphamide, prednisone, four rounds of plasmapheresis and ten cycles of rituximab. The data suggests that de-novo antibody responses do not play a significant role in the control of viral replication in these patients.

Full Text

Duke Authors

Cited Authors

  • Gaillard, S; Dinoso, JB; Marsh, JA; DeZern, AE; O'Connell, KA; Spivak, AM; Alwood, K; Durand, CM; Ambinder, RF; Blankson, JN

Published Date

  • July 2011

Published In

Volume / Issue

  • 51 / 3

Start / End Page

  • 195 - 198

PubMed ID

  • 21550842

Pubmed Central ID

  • PMC3117974

Electronic International Standard Serial Number (EISSN)

  • 1873-5967

Digital Object Identifier (DOI)

  • 10.1016/j.jcv.2011.04.002


  • eng

Conference Location

  • Netherlands