Sustained elite suppression of replication competent HIV-1 in a patient treated with rituximab based chemotherapy.
The mechanism of elite control of HIV-1 replication is not fully understood. While immunosuppression due to rituximab based chemotherapy has been associated with increased replication of HBV, CMV, and HIV-1, control of replication-competent HIV-1 was maintained in an elite controller/suppressor treated with a regimen that included vincristine, cyclophosphamide, prednisone, four rounds of plasmapheresis and ten cycles of rituximab. The data suggests that de-novo antibody responses do not play a significant role in the control of viral replication in these patients.
Gaillard, S; Dinoso, JB; Marsh, JA; DeZern, AE; O'Connell, KA; Spivak, AM; Alwood, K; Durand, CM; Ambinder, RF; Blankson, JN
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