High FSH:LH ratio and low LH levels in basal cycle day 3: impact on follicular development and IVF outcome.

Journal Article (Journal Article)

PURPOSE: To examine the impact of low basal cycle day 3 serum LH levels or a high FSH:LH ratio on IVF results. METHODS: A homogeneous group of patients was analyzed as identified by normal basal cycle of follicle stimulating hormone (FSH), Luteinizing hormone (LH), and estradiol (E2) levels. High responders (high LH:FSH ratio) and low responders (high FSH or E2 levels, and women > or = 42 years of age) were excluded from analysis. Only cycles stimulated with a combination of a GnRHa (luteal suppression) and pure FSH were studied. RESULTS: Patients with low basal LH levels (< 3 mIU/mL) did not differ significantly from controls in terms of response to controlled ovarian hyperstimulation but there was a clear trend toward poorer implantation and clinical pregnancy rates. On the other hand, patients with a high FSH:LH ratio (> 3) had significantly fewer mature oocytes aspirated, and lower implantation and clinical pregnancy rates than patients with gonadotropin ratio < or = 3. These negative effects were evident in the presence of normal basal FSH levels and after adequate matching of female's age and number of embryos transferred. CONCLUSIONS: These studies highlight a negative impact of a basal cycle high FSH:LH ratio (and possibly low LH levels) on follicular development and oocyte quality in these patients subjected to pituitary down-regulation followed by pure FSH administration. A high FSH:LH ratio may be therefore used as an early biomarker of poor ovarian response.

Full Text

Duke Authors

Cited Authors

  • Barroso, G; Oehninger, S; Monzó, A; Kolm, P; Gibbons, WE; Muasher, SJ

Published Date

  • September 2001

Published In

Volume / Issue

  • 18 / 9

Start / End Page

  • 499 - 505

PubMed ID

  • 11665665

Pubmed Central ID

  • PMC3455729

International Standard Serial Number (ISSN)

  • 1058-0468

Digital Object Identifier (DOI)

  • 10.1023/a:1016601110424


  • eng

Conference Location

  • Netherlands