High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders.

Journal Article (Journal Article)

OBJECTIVE: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. DESIGN: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. SETTING: Academic tertiary center. PATIENTS: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. INTERVENTIONS: All patients were stimulated using a combination of a GnRH-agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). MAIN OUTCOME MEASURES: Implantation and pregnancy (clinical and ongoing) rates were compared. RESULTS: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. CONCLUSIONS: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.

Full Text

Duke Authors

Cited Authors

  • Simon, T; Oehninger, S; Toner, J; Jones, D; Muasher, S

Published Date

  • June 1995

Published In

Volume / Issue

  • 63 / 6

Start / End Page

  • 1333 - 1336

PubMed ID

  • 7750610

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)57621-3


  • eng

Conference Location

  • United States