High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders.
Journal Article
OBJECTIVE: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. DESIGN: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. SETTING: Academic tertiary center. PATIENTS: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. INTERVENTIONS: All patients were stimulated using a combination of a GnRH-agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). MAIN OUTCOME MEASURES: Implantation and pregnancy (clinical and ongoing) rates were compared. RESULTS: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. CONCLUSIONS: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.
Full Text
Duke Authors
Cited Authors
- Simon, T; Oehninger, S; Toner, J; Jones, D; Muasher, S
Published Date
- June 1995
Published In
Volume / Issue
- 63 / 6
Start / End Page
- 1333 - 1336
PubMed ID
- 7750610
Pubmed Central ID
- 7750610
International Standard Serial Number (ISSN)
- 0015-0282
Digital Object Identifier (DOI)
- 10.1016/s0015-0282(16)57621-3
Language
- eng
Conference Location
- United States