Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.


Journal Article

Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.

Full Text

Duke Authors

Cited Authors

  • Acosta, AA; Oehninger, S; Hammer, J; Muasher, SJ; Liang, HM; Jones, DL

Published Date

  • April 1990

Published In

Volume / Issue

  • 53 / 4

Start / End Page

  • 673 - 676

PubMed ID

  • 2318326

Pubmed Central ID

  • 2318326

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)53462-1


  • eng

Conference Location

  • United States