Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.

Journal Article (Journal Article)

Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.

Full Text

Duke Authors

Cited Authors

  • Acosta, AA; Oehninger, S; Hammer, J; Muasher, SJ; Liang, HM; Jones, DL

Published Date

  • April 1990

Published In

Volume / Issue

  • 53 / 4

Start / End Page

  • 673 - 676

PubMed ID

  • 2318326

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)53462-1


  • eng

Conference Location

  • United States