Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.
Published
Journal Article
Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
Full Text
Duke Authors
Cited Authors
- Acosta, AA; Oehninger, S; Hammer, J; Muasher, SJ; Liang, HM; Jones, DL
Published Date
- April 1990
Published In
Volume / Issue
- 53 / 4
Start / End Page
- 673 - 676
PubMed ID
- 2318326
Pubmed Central ID
- 2318326
International Standard Serial Number (ISSN)
- 0015-0282
Digital Object Identifier (DOI)
- 10.1016/s0015-0282(16)53462-1
Language
- eng
Conference Location
- United States