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Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?

Publication ,  Journal Article
Karande, VC; Lester, RG; Muasher, SJ; Jones, DL; Acosta, AA; Jones, HW
Published in: Fertil Steril
August 1990

Forty-six infertile women with a history of diethylstilbestrol (DES) exposure in utero underwent 149 stimulation attempts for in vitro fertilization (IVF). The mean (+/- SE) number of preovulatory oocytes harvested at retrieval and transferred was 3.9 +/- 3.3 (536/138) and 2.6 +/- 1.4 (328/124). When compared with patients with tubal factor infertility and less than or equal to 4 pre-embryos transferred, the clinical pregnancy rate (15.3% versus 22%) was not statistically different. However, the term/ongoing pregnancy rate was significantly lower in the study group (8% versus 16%). Comparison of the IVF outcome with different uterine anomalies as detected by hysterosalpingogram (n = 29) showed a trend for a worse prognosis in women with constrictions and a combination of T-shape and constrictions. It is concluded that implantation and pregnancy outcome are impaired in DES-exposed women after IVF.

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

August 1990

Volume

54

Issue

2

Start / End Page

287 / 291

Location

United States

Related Subject Headings

  • Uterus
  • Prenatal Exposure Delayed Effects
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Hysterosalpingography
  • Humans
  • Fertilization in Vitro
  • Female
  • Embryo Transfer
 

Citation

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Chicago
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Karande, V. C., Lester, R. G., Muasher, S. J., Jones, D. L., Acosta, A. A., & Jones, H. W. (1990). Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer? Fertil Steril, 54(2), 287–291. https://doi.org/10.1016/s0015-0282(16)53705-4
Karande, V. C., R. G. Lester, S. J. Muasher, D. L. Jones, A. A. Acosta, and H. W. Jones. “Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?Fertil Steril 54, no. 2 (August 1990): 287–91. https://doi.org/10.1016/s0015-0282(16)53705-4.
Karande VC, Lester RG, Muasher SJ, Jones DL, Acosta AA, Jones HW. Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer? Fertil Steril. 1990 Aug;54(2):287–91.
Karande, V. C., et al. “Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer?Fertil Steril, vol. 54, no. 2, Aug. 1990, pp. 287–91. Pubmed, doi:10.1016/s0015-0282(16)53705-4.
Karande VC, Lester RG, Muasher SJ, Jones DL, Acosta AA, Jones HW. Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer? Fertil Steril. 1990 Aug;54(2):287–291.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

August 1990

Volume

54

Issue

2

Start / End Page

287 / 291

Location

United States

Related Subject Headings

  • Uterus
  • Prenatal Exposure Delayed Effects
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Hysterosalpingography
  • Humans
  • Fertilization in Vitro
  • Female
  • Embryo Transfer