Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone.

Journal Article (Clinical Trial;Journal Article)

There is a subset of patients who fail to respond adequately to exogenous gonadotropin stimulation for in vitro fertilization (IVF). In this study, six such low-responder patients who had inadequate stimulations with high-dose intramuscular (im) follicle stimulating hormone (FSH) were treated in a subsequent cycle with pulsatile intravenous (iv) FSH. A paired analysis was performed to compare the cycles using high-dose im FSH with those using pulsatile iv FSH. Trough serum FSH levels were significantly higher with pulsatile iv FSH. No significant difference was noted in the stimulation characteristics or the number or quality of oocytes retrieved and embryos transferred. No pregnancies occurred in either group. While pulsatile iv administration of gonadotropin increases serum FSH levels, it does not appear to have a major impact on follicular stimulation or outcome in low-responder patients undergoing IVF.

Full Text

Duke Authors

Cited Authors

  • Edelstein, MC; Brzyski, RG; Jones, GS; Muasher, SJ

Published Date

  • October 1990

Published In

Volume / Issue

  • 7 / 5

Start / End Page

  • 275 - 279

PubMed ID

  • 2123917

International Standard Serial Number (ISSN)

  • 0740-7769

Digital Object Identifier (DOI)

  • 10.1007/BF01129534


  • eng

Conference Location

  • United States