Delayed fertilization during in vitro fertilization and embryo transfer cycles: analysis of causes and impact on overall results.


Journal Article

This study evaluated possible causes of delayed fertilization during in vitro fertilization (IVF) cycles, its repetitiveness, and its influence on IVF results in 23 patients (27 cycles) with delayed fertilization of greater than or equal to 1 preovulatory oocyte(s). In 15 cycles, reinsemination with husband's semen was performed at 18 hours. Possible causes of delayed fertilization were oocyte defects (10 cycles, 37.0%), sperm defects (4 cycles, 14.8%), oocyte and sperm defects (4 cycles, 14.8%), and no detectable gamete defects (9 cycles, 33.3%). Overall fertilization rate was 47.9%. No pregnancies were observed in 10 patients with one embryo transferred. Recurrence rate of delayed fertilization per patient was 17.3%; overall ongoing pregnancy rate/cycle was 10.3%. Although repetitiveness of delayed fertilization is low, it seems to impact negatively on IVF results.

Full Text

Duke Authors

Cited Authors

  • Oehninger, S; Acosta, AA; Veeck, LL; Simonetti, S; Muasher, SJ

Published Date

  • December 1989

Published In

Volume / Issue

  • 52 / 6

Start / End Page

  • 991 - 997

PubMed ID

  • 2591576

Pubmed Central ID

  • 2591576

International Standard Serial Number (ISSN)

  • 0015-0282

Digital Object Identifier (DOI)

  • 10.1016/s0015-0282(16)53164-1


  • eng

Conference Location

  • United States