A Hough transform global probabilistic approach to multiple-subject diffusion MRI tractography.

Journal Article (Journal Article)

A global probabilistic fiber tracking approach based on the voting process provided by the Hough transform is introduced in this work. The proposed framework tests candidate 3D curves in the volume, assigning to each one a score computed from the diffusion images, and then selects the curves with the highest scores as the potential anatomical connections. The algorithm avoids local minima by performing an exhaustive search at the desired resolution. The technique is easily extended to multiple subjects, considering a single representative volume where the registered high-angular resolution diffusion images (HARDI) from all the subjects are non-linearly combined, thereby obtaining population-representative tracts. The tractography algorithm is run only once for the multiple subjects, and no tract alignment is necessary. We present experimental results on HARDI volumes, ranging from simulated and 1.5T physical phantoms to 7T and 4T human brain and 7T monkey brain datasets.

Full Text

Duke Authors

Cited Authors

  • Aganj, I; Lenglet, C; Jahanshad, N; Yacoub, E; Harel, N; Thompson, PM; Sapiro, G

Published Date

  • August 2011

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 414 - 425

PubMed ID

  • 21376655

Pubmed Central ID

  • PMC3115463

Electronic International Standard Serial Number (EISSN)

  • 1361-8423

International Standard Serial Number (ISSN)

  • 1361-8415

Digital Object Identifier (DOI)

  • 10.1016/j.media.2011.01.003


  • eng