Vascular-targeted photothermal therapy of an orthotopic murine glioma model.

Published

Journal Article

To develop nanoshells for vascular-targeted photothermal therapy of glioma.The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to thermally ablate VEGF receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent in vivo studies evaluated therapy in mice bearing intracerebral glioma tumors by exposing tumors to near-infrared light after systemically delivering saline, PEG-coated nanoshells, or VEGF-coated nanoshells. The treatment effect was monitored with intravital microscopy and histology.VEGF-coated but not PEG-coated nanoshells bound VEGF receptor-2-positive cells in vitro to enable targeted photothermal ablation. In vivo, VEGF targeting doubled the proportion of nanoshells bound to tumor vessels and vasculature was disrupted following laser exposure. Vessels were not disrupted in mice that received saline. The normal brain was unharmed in all treatment and control mice.Nanoshell therapy can induce vascular disruption in glioma.

Full Text

Duke Authors

Cited Authors

  • Day, ES; Zhang, L; Thompson, PA; Zawaski, JA; Kaffes, CC; Gaber, MW; Blaney, SM; West, JL

Published Date

  • August 2012

Published In

Volume / Issue

  • 7 / 8

Start / End Page

  • 1133 - 1148

PubMed ID

  • 22583571

Pubmed Central ID

  • 22583571

Electronic International Standard Serial Number (EISSN)

  • 1748-6963

International Standard Serial Number (ISSN)

  • 1743-5889

Digital Object Identifier (DOI)

  • 10.2217/nnm.11.189

Language

  • eng