Three-dimensional biomimetic patterning in hydrogels to guide cellular organization.

Journal Article (Journal Article)

An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.

Full Text

Duke Authors

Cited Authors

  • Culver, JC; Hoffmann, JC; Poché, RA; Slater, JH; West, JL; Dickinson, ME

Published Date

  • May 2012

Published In

Volume / Issue

  • 24 / 17

Start / End Page

  • 2344 - 2348

PubMed ID

  • 22467256

Pubmed Central ID

  • PMC3728891

Electronic International Standard Serial Number (EISSN)

  • 1521-4095

International Standard Serial Number (ISSN)

  • 0935-9648

Digital Object Identifier (DOI)

  • 10.1002/adma.201200395


  • eng