Biofunctional materials for directing vascular development.

Journal Article (Review;Journal Article)

Engineered tissue constructs are inherently limited by their lack of microvascularization. Evidence suggests that combining a scaffold material with cells and their cell-secreted signals instigates tubule formation, and various strategies can be employed to tailor the vascular response. This review focuses on rationally designed materials capable of supporting functional neovessel formation and stabilization. Biomaterial scaffolds and their use as growth factor delivery systems are discussed, as well as other functional enhancement strategies to direct cellular responses for effective formation of a mature vascular network.

Full Text

Duke Authors

Cited Authors

  • Saik, JE; McHale, MK; West, JL

Published Date

  • May 2012

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 331 - 341

PubMed ID

  • 22239635

Electronic International Standard Serial Number (EISSN)

  • 1875-6212

International Standard Serial Number (ISSN)

  • 1570-1611

Digital Object Identifier (DOI)

  • 10.2174/157016112799959314


  • eng