PEGDA hydrogels with patterned rigidity for manipulating cell behavior

Journal Article

PEGDA hydrogels with patterned and gradient elasticity are attractive substrates for the study of cell response to substrate rigidity. Using PEGDA hydrogels with tailored mechanical profiles, we are able to show differences in SMC behavior with substrate elasticity within a single sample. These substrates allow for the investigation of edge effects between substrates of different elasticity, effects of anisotropy on cellular behavior, screening of the effects of a wide range of substrate elasticity on cellular behavior, and investigation of cellular migration in response to a gradient of elasticity.

Duke Authors

Cited Authors

  • Nemir, S; McHale, MK; West, JL

Published Date

  • December 1, 2008

Published In

  • 8th World Biomaterials Congress 2008

Volume / Issue

  • 2 /

Start / End Page

  • 894 -

Citation Source

  • Scopus