Gold nanoshells aided optical imaging in vitro, in vivo, and ex vivo
Scatter-based optical imaging technologies such as Optical Coherence Tomography (OCT) and Reflectance Confocal Microscopy (RCM) offer a unique non-invasive approach to the detection, diagnosis, and monitoring of cancer. In this article, we describe the use of targeted NIR-tuned gold nanoshell for imaging in vitro, ex vivo and in vivo. Nanoshells are a new class of optically active nanoparticles with tunable plasmon resonances based on geometric construction. These particles can be easily tuned to absorb or scatter strongly within the wavelengths of 650-1300 nm, known as the near infrared region. This region is of significant biological importance providing a therapeutic window and imaging applications in tissue as the primary components of tissue, blood and water, do not have significant absorption coefficients in this range of wavelengths.
Lee, M; Loo, C; Gobin, AM; Park, J; West, J; Halas, N; Drezek, R
2007 Nsti Nanotechnology Conference and Trade Show Nsti Nanotech 2007, Technical Proceedings
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