Nitric oxide-generating poly(ethylene glycol) copolymers for prevention of restenosis
Nitric oxide (NO)-generating poly(ethylene glycol) copolymers were synthesized and characterized for prevention of restenosis. Vessel re-endothelialization found to be slightly enhanced in the presence of the NO-generating hydrogels. The results indicate that localized delivery of NO from these hydrogels can significantly inhibit neointimal formation in a rat carotid balloon injury model. It was found that the combined effects of these hydrogels make them well suited for use as a stent coating or in endoluminal paving to prevent restenosis.