Nitric oxide-generating poly(ethylene glycol) copolymers for prevention of restenosis


Journal Article

Nitric oxide (NO)-generating poly(ethylene glycol) copolymers were synthesized and characterized for prevention of restenosis. Vessel re-endothelialization found to be slightly enhanced in the presence of the NO-generating hydrogels. The results indicate that localized delivery of NO from these hydrogels can significantly inhibit neointimal formation in a rat carotid balloon injury model. It was found that the combined effects of these hydrogels make them well suited for use as a stent coating or in endoluminal paving to prevent restenosis.

Duke Authors

Cited Authors

  • Lipke, EA; Masters, KS; West, JL

Published Date

  • December 1, 2004

Published In

  • Aiche Annual Meeting, Conference Proceedings

Start / End Page

  • 6343 - 6344

Citation Source

  • Scopus