Inhibition of intimal thickening in a rat model of balloon angioplasty using NO-generating hydrogels
The ability of nitrogen oxide (NO)-generating hydrogels to inhibit thickening in a rat carotid injury model was discussed. It was observed that the perivascular application of NO-generating hydrogels reduced neointima formation in the balloon injury model as compared to control hydrogels. polyethylene glycol (PEG)-NO-nucleophile was formed by reacting polyethylene glycol N-hydroxysuccinimide monoacrylate with cysteine (Cys). It was found that the combined effects of NO-generating hydrogels made them suitable for use as a stent coating or in endoluminal paving to prevent restenosis.