Photothermal tumor therapy using metal nanoshells


Journal Article

A minimally, invasive photothermal cancer therapy using metal nanoshells was discussed. Nanoshells, consisting of a silica core surrounded by a thin gold shell, were new class of nanoparticle with an optical tunability that cover the visible to the near infrared (NIR) region. Complete weakening of tumors was observed in animals receiving systematic injections of nanoshells before NIR laser treatment. The results show that the systematic delivery of nanoshells in vivo provide sufficient tumor accumulation for selective heating and complete ablation of tumors, producing 100% cure rates.

Duke Authors

Cited Authors

  • Lowery, A; O'Neal, P; Hirsch, L; Halas, N; West, J

Published Date

  • December 1, 2004

Published In

  • Transactions 7th World Biomaterials Congress

Start / End Page

  • 694 -

Citation Source

  • Scopus