Poly(ethylene glycol)-based copolymers for local delivery of nitric oxide
Poly(ethylene glycol)-based copolymers were synthesized for local delivery of nitric oxide (NO). Dendrimers were formed using liquid phase peptide synthesis. NO release from each generation of dendrimer species was determined by incubating dendrimers under physiological conditions and monitoring NO release by the Griess assay. The coupling of lysine to the dendrimer cores was monitored by Ninhydrin assay and exceeded 80%. The results confirm the ability of these materials in delivering therapeutic doses of NO to physiological systems.