Hydrogel scaffolds with immobilized bFGF: Effects on SMCs
To optimize tissue formation, we propose the use of polyethylene glycol (PEG) conjugated growth factors that can be covalently immobilized to scaffolds. In this study, hydrogel scaffolds were modified with basic fibroblast growth factor (bFGF), which is a potent mitogen for many cell types. We have demonstrated that bFGF retains its activity following attachment to PEG and following covalent incorporation into photopolymerized hydrogel scaffolds. Further, an immobilized gradient of bFGF was formed in hydrogels, causing cells to align in the direction of increasing bFGF content.
Transactions 7th World Biomaterials Congress
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