The use of gold nanoshells for the molecular imaging of breast cancer was discussed. The detection of the Her-2/neu receptors expressed on the cell membrane was also discussed. The formation of gold nanoshells was analyzed with a UV-Vis spectrophotometer and scanning electron microscopy. The sample nanoshells has a silica core diameter of 240 nm with a 35 nm gold shell. Scattering-based optical imaging modalities, coupled with targeted optical contrast agents, offer a new approach to clinical cancer imaging.