Bioactive microporous PEG/YIGSR polyurethaneureas for use as small diameter vascular grafts


Journal Article

The development of a YIGSR peptide- and PEG-modified polyurethaneurea by incorporating YIGSR peptide sequences as a chain extender and PEG as a soft segment was studied. Bovine aortic endothelial cells (BAEC) were seeded on polymer films to evaluate biological performance. Collagen I and polyurethaneurea films were incubated with mepacrine-labeled whole blood at 25°C to evaluate platelet adhesion. Using gas foaming and salt leaching via incorporation of sodium bicarbonate, scaffolds were fabricated. It was observed that the number of cells that migrated through the PUUYIGSR-PEG matrices was significantly greater than for PEG-containing polyurethane urea (PUUPPD-PEG).

Duke Authors

Cited Authors

  • Jun, HW; West, JL

Published Date

  • December 1, 2004

Published In

  • Transactions 7th World Biomaterials Congress

Start / End Page

  • 709 -

Citation Source

  • Scopus