Bioactive microporous PEG/YIGSR polyurethaneureas for use as small diameter vascular grafts
The development of a YIGSR peptide- and PEG-modified polyurethaneurea by incorporating YIGSR peptide sequences as a chain extender and PEG as a soft segment was studied. Bovine aortic endothelial cells (BAEC) were seeded on polymer films to evaluate biological performance. Collagen I and polyurethaneurea films were incubated with mepacrine-labeled whole blood at 25°C to evaluate platelet adhesion. Using gas foaming and salt leaching via incorporation of sodium bicarbonate, scaffolds were fabricated. It was observed that the number of cells that migrated through the PUUYIGSR-PEG matrices was significantly greater than for PEG-containing polyurethane urea (PUUPPD-PEG).