Localized delivery of anti-heparanase for inhibition of restenosis

We have used hydrogel systems to locally deliver a possible inhibitor of restenosis. This inhibitor is an antibody against the active site of platelet-derived heparanase. This enzyme is involved in the activation of basic fibroplast growth factor stored in the extracellular matrix following vascular injury. The antibody was found to inhibit bFGF release from the arterial wall and to decrease intimal thickening by 60% (n=7; p<0.00003).

Duke Authors

Cited Authors

  • Myler, HA; Rice, E; West, JL

Published Date

  • 2002

Published In

  • Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volume / Issue

  • 1 /

Start / End Page

  • 528 - 529

Citation Source

  • SciVal