Photopolymerized hydrogels as scaffolds for tissue engineered vascular grafts
A study was conducted to examine viability, DNA content, proliferation, and matrix production of SMCs and ECs in PEGDA hydrogels. Over four weeks, SMCs and ECs remained viable. Through one week, DNA increased significantly, cells stained positive for proliferating cell nuclear antigen, and cells produced collagen, indicating that cells within PEG-based hydrogel scaffolds are involved in forming new tissue. Also, the mechanical properties of PEGDA hydrogels; were examined. Hydrogels of 3400 Da had a Young's modulus of 2.3×105 Pa and an ultimate tensile strength of 3.1× 104 Pa, while the 6000 and 10,000 Da hydrogels had a Young's modulus and ultimate tensile strength an order of magnitude lower. The 20% wt 600/6000 hydrogel blend significantly increased Young's modulus.
Schmedlen, R; Mann, B; West, J
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