Synthetic ECM analogs as tissue engineering scaffolds


Journal Article

A study was performed to evaluate three proteolytically degradable PEG hydrogels formed by including a degradable peptide in the polymer backbone: LGPA for a collagenase-sensitive polymer, NRV for a plasmin-sensitive polymer, and a polyalanine for an elastase-sensitive polymer. It was shown that the ligands significantly increase adhesion to smooth muscle cells (SMCs). Also, covalently tethered transforming growth factor-beta to the hydrogel scaffold caused increased ECM protein production by SMC was covalently tethered.

Duke Authors

Cited Authors

  • Mann, B; Goin, A; Tsai, A; West, J

Published Date

  • December 1, 2000

Published In

Volume / Issue

  • 28 / SUPPL. 1

International Standard Serial Number (ISSN)

  • 0090-6964

Citation Source

  • Scopus