Near-infrared thermally-induced cell death using metal nanoshells
Antibodies were conjugated to metal nanoshells with retained activity. Nanoshells demonstrated local photothermally-induced death of human dermal fibroblasts (HDFs) in vitro. Gold-gold sulfide nanoshells with a peak absorbance at 830nm were incubated with HDFs, followed by irradiation for 30 s, 1.5, 10, and 20 min. Control surfaces were treated under identical conditions without the nanoshells. In general, significant results were obtained.
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