Interfacially photopolymerized hydrogels for local vascular drug delivery


Journal Article

An interfacial photopolymerization method for the intravascular application of thin hydrogel barriers was developed. The hydrogels are well suited for localized intravascular delivery of hydrophilic macromolecules dissolved in the aqueous precursor solution and entrapped in the hydrogel after illumination. It was found that when platelet derived growth factor (PDGF) was locally delivered from the photopolymerized hydrogel after vascular injury, the thickness of the intimal layer of the arterial wall increased markedly. A protein can be delivered from a photopolymerized hydrogel while retaining its biological activity and the released protein can permeate through the vessel wall to act upon its target, medial smooth muscle cells.

Duke Authors

Cited Authors

  • West, JL; An, Y; Hubbell, JA

Published Date

  • December 1, 1996

Published In

  • Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium

Volume / Issue

  • 1 /

Start / End Page

  • 645 -

Citation Source

  • Scopus