Electroactive controlled release thin films.

Published

Journal Article

We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their contents after the application of a voltage and then to restabilize upon its removal. As a result, it is possible to externally trigger agent release, exert control over the relative quantity of agents released from a film, and release multiple doses from one or more films in a single solution. These electroactive systems may be rapidly and conformally coated onto a wide range of substrates without regard to size, shape, or chemical composition, and as such they may find use in a host of new applications in drug delivery as well as the related fields of tissue engineering, medical diagnostics, and chemical detection.

Full Text

Duke Authors

Cited Authors

  • Wood, KC; Zacharia, NS; Schmidt, DJ; Wrightman, SN; Andaya, BJ; Hammond, PT

Published Date

  • February 19, 2008

Published In

Volume / Issue

  • 105 / 7

Start / End Page

  • 2280 - 2285

PubMed ID

  • 18272499

Pubmed Central ID

  • 18272499

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.0706994105

Language

  • eng

Conference Location

  • United States