Potential role for statins in sickle cell disease.

Journal Article (Journal Article;Review)

The complex pathophysiology of sickle cell disease (SCD) is remarkably similar to that observed in other chronic vascular diseases and involves multiple biologic pathways triggered by ischemia reperfusion injury, coagulation activation, and inflammation. Statins are potent lipid-lowering agents commonly used to reduce the risk of cardiovascular disease. Independent of their lipid lowering effect, statins have been shown to down-regulate inflammatory mediators and endothelial adhesion molecules, reduce tissue factor expression and restore nitric oxide bioavailability. The pleiotropic effects of statins make these agents attractive therapeutic candidates for SCD. This article reviews available evidence for the potential role of statins in SCD.

Full Text

Duke Authors

Cited Authors

  • Adam, SS; Hoppe, C

Published Date

  • April 2013

Published In

Volume / Issue

  • 60 / 4

Start / End Page

  • 550 - 557

PubMed ID

  • 23281161

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.24443


  • eng

Conference Location

  • United States