High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity.

Published

Journal Article

Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe veno-occlusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m2) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential.

Full Text

Duke Authors

Cited Authors

  • Jones, RB; Shpall, EJ; Ross, M; Coniglio, D; Affronti, ML; Peters, WP

Published Date

  • 1990

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 155 - 156

PubMed ID

  • 2189592

Pubmed Central ID

  • 2189592

International Standard Serial Number (ISSN)

  • 0344-5704

Digital Object Identifier (DOI)

  • 10.1007/bf02897264

Language

  • eng

Conference Location

  • Germany