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Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema.

Publication ,  Journal Article
Diabetic Retinopathy Clinical Research Network, ; Danis, RP; Glassman, AR; Aiello, LP; Antoszyk, AN; Beck, RW; Browning, DJ; Ciardella, AP ...
Published in: Arch Ophthalmol
December 2006

OBJECTIVE: To evaluate diurnal variation in retinal thickness measured with optical coherence tomography (OCT) in patients with center-involved diabetic macular edema. METHODS: Serial OCT3 measurements were performed in 156 eyes of 96 subjects with clinically diagnosed diabetic macular edema and OCT central subfield retinal thickness of 225 microm or greater at 8 am. Central subfield thickness was measured from OCT3 retinal thickness maps at 6 points over a single day between 8 am and 4 pm. A change in central subfield thickening (observed thickness minus mean normal thickness) of at least 25% and of at least 50 microm at 2 consecutive points or between 8 am and 4 pm was considered to have met the composite outcome threshold. RESULTS: At 8 am, the mean central subfield thickness was 368 microm and the mean visual acuity was 66 letters (approximately 20/50). The mean change in relative central subfield retinal thickening between 8 am and 4 pm was a decrease of 6% (95% confidence interval, -9% to -3%) and the mean absolute change was a decrease of 13 microm (95% CI, -17 to -8). The absolute change was significantly greater in retinas that were thicker at 8 am (P<.001) but the relative change was not (P = .14). The composite threshold of reduction in central subfield thickening (as defined above) was observed in 5 eyes of 4 subjects (3% of eyes; 95% CI, 1% to 8%) while 2 eyes of 2 subjects (1%; 95% CI, 0% to 5%) had an increase in central subfield thickening of this same magnitude. The maximum decrease was observed at 4 pm in all 5 eyes. CONCLUSION: Although on average there are slight decreases in retinal thickening during the day, most eyes with diabetic macular edema have little meaningful change in OCT central subfield thickening between 8 am and 4 pm.

Duke Scholars

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

December 2006

Volume

124

Issue

12

Start / End Page

1701 / 1707

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Time Factors
  • Retina
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diabetic Retinopathy Clinical Research Network, ., Danis, R. P., Glassman, A. R., Aiello, L. P., Antoszyk, A. N., Beck, R. W., … Wells, J. A. (2006). Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol, 124(12), 1701–1707. https://doi.org/10.1001/archopht.124.12.1701
Diabetic Retinopathy Clinical Research Network, John A., Ronald P. Danis, Adam R. Glassman, Lloyd Paul Aiello, Andrew N. Antoszyk, Roy W. Beck, David J. Browning, et al. “Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema.Arch Ophthalmol 124, no. 12 (December 2006): 1701–7. https://doi.org/10.1001/archopht.124.12.1701.
Diabetic Retinopathy Clinical Research Network, Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, et al. Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol. 2006 Dec;124(12):1701–7.
Diabetic Retinopathy Clinical Research Network, John A., et al. “Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema.Arch Ophthalmol, vol. 124, no. 12, Dec. 2006, pp. 1701–07. Pubmed, doi:10.1001/archopht.124.12.1701.
Diabetic Retinopathy Clinical Research Network, Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, Kinyoun JL, Murtha TJ, Topping TM, Shami M, Sharuk GS, Wells JA. Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol. 2006 Dec;124(12):1701–1707.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

December 2006

Volume

124

Issue

12

Start / End Page

1701 / 1707

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Time Factors
  • Retina
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
  • Humans
  • Female