A 102-center prospective study of seizure in association with bupropion.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

BACKGROUND: This trial was conducted to determine the incidence of seizures associated with the use of bupropion. METHOD: A total of 3341 depressed patients from 102 sites were enrolled in this 8-week, prospective, open trial. Following the 8-week treatment phase, patients could elect to enroll in a humanitarian continuation phase of unlimited duration. Dosing was initiated at 225 mg/day and increased to 450 mg/day as tolerated. Investigators carefully monitored seizure occurrences and rated their patients' response to and tolerance of bupropion. RESULTS: A total of 1986 patients (61%) completed the 8-week treatment phase, and 1616 (81%) of these elected to be maintained on bupropion treatment in the humanitarian continuation phase. The observed seizure rate was 0.24% for the treatment phase and 0.40% for the entire study. An 8-week survival analysis performed on patients with a dosing regimen of 300 to 450 mg/day yielded a cumulative rate of 0.36%. Patients, including those previously resistant to antidepressant treatment, responded to and tolerated bupropion well. CONCLUSION: These rates confirm earlier seizure estimates and fall within accepted parameters for antidepressant drugs. This trial enhances bupropion's position as a valuable alternative for the management of depression.

Full Text

Duke Authors

Cited Authors

  • Johnston, JA; Lineberry, CG; Ascher, JA; Davidson, J; Khayrallah, MA; Feighner, JP; Stark, P

Published Date

  • November 1991

Published In

Volume / Issue

  • 52 / 11

Start / End Page

  • 450 - 456

PubMed ID

  • 1744061

International Standard Serial Number (ISSN)

  • 0160-6689


  • eng

Conference Location

  • United States