Toward a systems analysis of the root.

Journal Article (Review;Journal Article)

During the past 20 years, our work on root development has been influenced by and has contributed to three biological approaches: molecular genetics, genomics, and systems biology. Characterization of mutations that affect root radial patterning led to the identification of a transcription factor that acts as both a signaling molecule and a key developmental regulator. Combining cell sorting with microarray analysis provided a platform for determining genome-wide expression profiles of mRNAs under standard and stress conditions, revealing a vast amount of tissue-specific response. A focus on connections among molecular components identified a tissue-specific gene regulatory network and a clock-like process that determines the position of lateral roots along the primary root axis. Finally, the genetic basis for the physical network of different roots that constitutes root system architecture is being dissected using automated imaging of growing root systems.

Full Text

Duke Authors

Cited Authors

  • Benfey, PN

Published Date

  • January 2012

Published In

Volume / Issue

  • 77 /

Start / End Page

  • 91 - 96

PubMed ID

  • 23234807

Pubmed Central ID

  • PMC3883509

Electronic International Standard Serial Number (EISSN)

  • 1943-4456

International Standard Serial Number (ISSN)

  • 0091-7451

Digital Object Identifier (DOI)

  • 10.1101/sqb.2012.77.014506


  • eng