Innate pathways of immune activation in transplantation.


Journal Article

Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells. Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutionarily primitive pathways, have demonstrated a critical role of the innate immune system in the regulation of the adaptive immune system. Innate immunity has been extensively studied in its role as the host's first-line defense against microbial pathogens; however, it is becoming increasingly recognized for its ability to also recognize host-derived molecules that result from tissue damage. The capacity of endogenous damage signals acting through the innate immune system to lower immune thresholds and promote immune recognition and rejection of transplant grafts is only beginning to be appreciated. An improved understanding of these pathways may reveal novel therapeutic targets to decrease graft alloreactivity and increase graft longevity.

Full Text

Duke Authors

Cited Authors

  • Brennan, TV; Lunsford, KE; Kuo, PC

Published Date

  • 2010

Published In

Volume / Issue

  • 2010 /

PubMed ID

  • 20871653

Pubmed Central ID

  • 20871653

Electronic International Standard Serial Number (EISSN)

  • 2090-0015

Digital Object Identifier (DOI)

  • 10.1155/2010/826240


  • eng

Conference Location

  • United States