Mechanisms of immune tolerance relevant to food allergy.


Journal Article

The intestine has an unenviable task: to identify and respond to a constant barrage of environmental stimuli that can be both dangerous and beneficial. The proper execution of this task is central to the homeostasis of the host, and as a result, the gastrointestinal tract contains more lymphocytes than any other tissue compartment in the body, as well as unique antigen-presenting cells with specialized functions. When antigen is initially encountered through the gut, this system generates a robust T cell-mediated hyporesponsiveness called oral tolerance. Although seminal observations of oral tolerance were made a century ago, the relevant mechanisms are only beginning to be unraveled with the use of modern investigational techniques. Food allergy is among the clinical disorders that occur from a failure of this system, and therapies that seek to re-establish tolerance are currently under investigation.

Full Text

Cited Authors

  • Vickery, BP; Scurlock, AM; Jones, SM; Burks, AW

Published Date

  • March 2011

Published In

Volume / Issue

  • 127 / 3

Start / End Page

  • 576 - 584

PubMed ID

  • 21277624

Pubmed Central ID

  • 21277624

Electronic International Standard Serial Number (EISSN)

  • 1097-6825

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2010.12.1116


  • eng

Conference Location

  • United States