Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery.

Journal Article (Review;Journal Article)

This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers. The emerging importance of both particle size and shape is considered, and the adaptation and modification of soft lithography methods to produce nanoparticles are highlighted. To this end, studies utilizing particles made via a process called Particle Replication In Non-wetting Templates are discussed. In addition, insights gained into therapeutic cargo and imaging agent delivery from related types of polymer-based carriers are considered.

Full Text

Duke Authors

Cited Authors

  • Canelas, DA; Herlihy, KP; DeSimone, JM

Published Date

  • July 2009

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 391 - 404

PubMed ID

  • 20049805

Pubmed Central ID

  • PMC2804992

Electronic International Standard Serial Number (EISSN)

  • 1939-0041

International Standard Serial Number (ISSN)

  • 1939-5116

Digital Object Identifier (DOI)

  • 10.1002/wnan.40


  • eng