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Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat.

Publication ,  Journal Article
Lu, SM; Lin, CS; Behan, M; Cant, NB; Hall, WC
Published in: Neuroscience
September 1985

Recent evidence suggests that gamma-aminobutyrate has a profound influence on the activity of premotor neurons in the intermediate grey layer of the superior colliculus. In the present study an antibody to glutamate decarboxylase, the synthesizing enzyme for gamma-aminobutyrate, was used to identify and characterize the structures in the intermediate grey layer of the cat that use gamma-aminobutyrate as a transmitter. The material was examined with both the light and electron microscope. Glutamate decarboxylase immunoreactivity was confined, for the most part, to axon terminals. Glutamate decarboxylase positive terminals almost completely cover the soma and proximal dendrites of the large neurons that are characteristic of this layer. Other glutamate decarboxylase positive terminals contact smaller, presumably more distal dendrites. By combining the glutamate decarboxylase immunocytochemistry with the retrograde transport of horseradish peroxidase in single animals, it was demonstrated that the cells of origin of the major descending efferent pathway from the intermediate grey layer, the predorsal bundle, are heavily contacted by glutamate decarboxylase immunoreactive terminals.

Duke Scholars

Published In

Neuroscience

DOI

ISSN

0306-4522

Publication Date

September 1985

Volume

16

Issue

1

Start / End Page

123 / 131

Location

United States

Related Subject Headings

  • Superior Colliculi
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Endings
  • Microscopy, Electron
  • Horseradish Peroxidase
  • Glutamate Decarboxylase
  • Cats
  • Brain Mapping
  • Biological Transport
 

Citation

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MLA
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Lu, S. M., Lin, C. S., Behan, M., Cant, N. B., & Hall, W. C. (1985). Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat. Neuroscience, 16(1), 123–131. https://doi.org/10.1016/0306-4522(85)90051-x
Lu, S. M., C. S. Lin, M. Behan, N. B. Cant, and W. C. Hall. “Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat.Neuroscience 16, no. 1 (September 1985): 123–31. https://doi.org/10.1016/0306-4522(85)90051-x.
Lu SM, Lin CS, Behan M, Cant NB, Hall WC. Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat. Neuroscience. 1985 Sep;16(1):123–31.
Lu, S. M., et al. “Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat.Neuroscience, vol. 16, no. 1, Sept. 1985, pp. 123–31. Pubmed, doi:10.1016/0306-4522(85)90051-x.
Lu SM, Lin CS, Behan M, Cant NB, Hall WC. Glutamate decarboxylase immunoreactivity in the intermediate grey layer of the superior colliculus in the cat. Neuroscience. 1985 Sep;16(1):123–131.
Journal cover image

Published In

Neuroscience

DOI

ISSN

0306-4522

Publication Date

September 1985

Volume

16

Issue

1

Start / End Page

123 / 131

Location

United States

Related Subject Headings

  • Superior Colliculi
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Endings
  • Microscopy, Electron
  • Horseradish Peroxidase
  • Glutamate Decarboxylase
  • Cats
  • Brain Mapping
  • Biological Transport