Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.

Journal Article (Clinical Trial;Journal Article)

The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 micrograms, 0.125 micrograms, 0.25 micrograms, 1 microgram, 250 micrograms) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Miller, MN; Helms, MJ; Reed, D; Ritchie, JC; Nemeroff, CB; Carroll, BJ

Published Date

  • 1993

Published In

Volume / Issue

  • 242 / 4

Start / End Page

  • 240 - 243

PubMed ID

  • 8384887

International Standard Serial Number (ISSN)

  • 0940-1334

Digital Object Identifier (DOI)

  • 10.1007/BF02189969


  • eng

Conference Location

  • Germany