Fast feedback regulation of ACTH by cortisol.

Journal Article (Journal Article)

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Ritchie, JC; Manepalli, AN; Saunders, W; Li, SW; Venkataraman, S; Nemeroff, CB; Carroll, BJ

Published Date

  • 1991

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 523 - 529

PubMed ID

  • 1661015

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/0278-5846(91)90027-x


  • eng

Conference Location

  • England