Androgen receptor activation by G(s) signaling in prostate cancer cells.

Published

Journal Article

The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated alpha subunit of heterotrimeric guanine nucleotide-binding G(s) protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The G alpha(s) activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for G alpha(s) and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.

Full Text

Duke Authors

Cited Authors

  • Kasbohm, EA; Guo, R; Yowell, CW; Bagchi, G; Kelly, P; Arora, P; Casey, PJ; Daaka, Y

Published Date

  • March 2005

Published In

Volume / Issue

  • 280 / 12

Start / End Page

  • 11583 - 11589

PubMed ID

  • 15653681

Pubmed Central ID

  • 15653681

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.m414423200

Language

  • eng