Androgen receptor activation by G(s) signaling in prostate cancer cells.
Published
Journal Article
The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated alpha subunit of heterotrimeric guanine nucleotide-binding G(s) protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The G alpha(s) activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for G alpha(s) and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.
Full Text
Duke Authors
Cited Authors
- Kasbohm, EA; Guo, R; Yowell, CW; Bagchi, G; Kelly, P; Arora, P; Casey, PJ; Daaka, Y
Published Date
- March 25, 2005
Published In
Volume / Issue
- 280 / 12
Start / End Page
- 11583 - 11589
PubMed ID
- 15653681
Pubmed Central ID
- 15653681
International Standard Serial Number (ISSN)
- 0021-9258
Digital Object Identifier (DOI)
- 10.1074/jbc.M414423200
Language
- eng
Conference Location
- United States