Prospective of Ras signaling in stem cells.

Journal Article (Review)

The Ras signaling pathway plays a predominant role during development and controls diverse biological process in all eukaryotic cells. It is a member of the large family of GTPases proteins that binds and hydrolyzes GTP. Ras is a lipid-anchored protein on the intracellular membrane compartments, and cycles between inactive GDP-bound and the signaling competent GTP-bound conformation. Studies have demonstrated Ras to be a central regulator in signal transduction pathways responding to diverse extracellular and intracellular stimuli. Much progress has been made towards delineating specific genes involved in the process of pluripotency and differentiation of stem cells. Here, we discuss recent aspects of Ras signaling pathways in mediating stem cell properties.

Full Text

Duke Authors

Cited Authors

  • Chakrabarty, K; Heumann, R

Published Date

  • July 2008

Published In

Volume / Issue

  • 389 / 7

Start / End Page

  • 791 - 798

PubMed ID

  • 18627319

International Standard Serial Number (ISSN)

  • 1431-6730

Digital Object Identifier (DOI)

  • 10.1515/BC.2008.104

Language

  • eng

Conference Location

  • Germany