Immobilisation stress induced analgesia in diabetic rats.

Journal Article (Journal Article)

Stress is known to produce analgesia. The pain threshold is altered in diabetes. We studied the effect of 1 hr of immobilisation stress on pain threshold in male Wistar rats. The same effect was tested in streptozotocin induced diabetic rats. The pain threshold of tail flick, vocalisation and vocalisation after discharge increased in the control group after the stress procedure. Significant analgesia was also obtained in diabetic rats, for flick and after discharge pain threshold. However the vocalisation threshold was not altered, probably due to the antagonistic action of glucose on opiate receptor at the level of brain stem.

Duke Authors

Cited Authors

  • Mahajan, AS; Mishra, TK; Chakrabarty, K; Chakrabarty, AS

Published Date

  • July 1997

Published In

Volume / Issue

  • 41 / 3

Start / End Page

  • 275 - 279

PubMed ID

  • 10232773

International Standard Serial Number (ISSN)

  • 0019-5499


  • eng