Growth hormone response to growth hormone releasing factor in Alzheimer's disease.


Journal Article

Because of the well-established reduction in the concentration of somatostatin in several brain areas of patients with histologically verified Alzheimer's disease, we sought to determine if growth hormone (GH) secretion is altered in Alzheimer's disease. In order to study this, we assessed the GH response to growth hormone releasing factor (GRF) in 8 patients with Alzheimer's disease and 8 age-matched controls. Although there was no difference between the magnitude of the GRF-induced GH response (delta max GH response or area under the curve) between the Alzheimer's disease patients and the controls, the Alzheimer's patients exhibited a delayed GH response to GRF.

Full Text

Duke Authors

Cited Authors

  • Nemeroff, CB; Krishnan, KR; Belkin, BM; Ritchie, JC; Clark, C; Vale, WW; Rivier, JE; Thorner, MO

Published Date

  • December 1989

Published In

Volume / Issue

  • 50 / 6

Start / End Page

  • 663 - 666

PubMed ID

  • 2515465

Pubmed Central ID

  • 2515465

International Standard Serial Number (ISSN)

  • 0028-3835

Digital Object Identifier (DOI)

  • 10.1159/000125296


  • eng

Conference Location

  • Switzerland