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Growth hormone response to growth hormone releasing factor in Alzheimer's disease.

Publication ,  Journal Article
Nemeroff, CB; Krishnan, KR; Belkin, BM; Ritchie, JC; Clark, C; Vale, WW; Rivier, JE; Thorner, MO
Published in: Neuroendocrinology
December 1989

Because of the well-established reduction in the concentration of somatostatin in several brain areas of patients with histologically verified Alzheimer's disease, we sought to determine if growth hormone (GH) secretion is altered in Alzheimer's disease. In order to study this, we assessed the GH response to growth hormone releasing factor (GRF) in 8 patients with Alzheimer's disease and 8 age-matched controls. Although there was no difference between the magnitude of the GRF-induced GH response (delta max GH response or area under the curve) between the Alzheimer's disease patients and the controls, the Alzheimer's patients exhibited a delayed GH response to GRF.

Duke Scholars

Published In

Neuroendocrinology

DOI

ISSN

0028-3835

Publication Date

December 1989

Volume

50

Issue

6

Start / End Page

663 / 666

Location

Switzerland

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Growth Hormone-Releasing Hormone
  • Growth Hormone
  • Female
  • Endocrinology & Metabolism
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged
 

Citation

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Nemeroff, C. B., Krishnan, K. R., Belkin, B. M., Ritchie, J. C., Clark, C., Vale, W. W., … Thorner, M. O. (1989). Growth hormone response to growth hormone releasing factor in Alzheimer's disease. Neuroendocrinology, 50(6), 663–666. https://doi.org/10.1159/000125296
Nemeroff, C. B., K. R. Krishnan, B. M. Belkin, J. C. Ritchie, C. Clark, W. W. Vale, J. E. Rivier, and M. O. Thorner. “Growth hormone response to growth hormone releasing factor in Alzheimer's disease.Neuroendocrinology 50, no. 6 (December 1989): 663–66. https://doi.org/10.1159/000125296.
Nemeroff CB, Krishnan KR, Belkin BM, Ritchie JC, Clark C, Vale WW, et al. Growth hormone response to growth hormone releasing factor in Alzheimer's disease. Neuroendocrinology. 1989 Dec;50(6):663–6.
Nemeroff, C. B., et al. “Growth hormone response to growth hormone releasing factor in Alzheimer's disease.Neuroendocrinology, vol. 50, no. 6, Dec. 1989, pp. 663–66. Pubmed, doi:10.1159/000125296.
Nemeroff CB, Krishnan KR, Belkin BM, Ritchie JC, Clark C, Vale WW, Rivier JE, Thorner MO. Growth hormone response to growth hormone releasing factor in Alzheimer's disease. Neuroendocrinology. 1989 Dec;50(6):663–666.
Journal cover image

Published In

Neuroendocrinology

DOI

ISSN

0028-3835

Publication Date

December 1989

Volume

50

Issue

6

Start / End Page

663 / 666

Location

Switzerland

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Growth Hormone-Releasing Hormone
  • Growth Hormone
  • Female
  • Endocrinology & Metabolism
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged