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The science of neonatal high-frequency ventilation.

Publication ,  Journal Article
Cotten, M; Clark, RH
Published in: Respir Care Clin N Am
December 2001

Despite improvements in respiratory care, ventilator-induced lung injury remains an important cause of morbidity and mortality in neonates who require assisted ventilation. Animal data clearly demonstrate that high-frequency ventilation can be used successfully to reduce lung injury in experimental models of acute lung injury. These models and human research show that the efficacy of high-frequency ventilation is dependent on optimizing functional residual capacity and avoiding lung overinflation. When used with a strategy that promotes lung recruitment, high-frequency ventilation effectively reduces the occurrence of chronic lung disease and is not associated with significant brain injury. When used with a strategy that allows the lung to collapse or is associated with hyperventilation, however, high-frequency ventilation does not reduce lung injury and is associated with significant brain injury. Like every tool we use to support critically ill neonates, high-frequency ventilation needs a careful carpenter. As therapies and health care strategies evolve, there remains nothing more important than the health care team at the bedside. Critical evaluation of the patient and his or her response to the therapy being offered is essential to promotion of the patient health outcome.

Duke Scholars

Published In

Respir Care Clin N Am

DOI

ISSN

1078-5337

Publication Date

December 2001

Volume

7

Issue

4

Start / End Page

611 / 631

Location

United States

Related Subject Headings

  • Respiratory System
  • Respiratory Insufficiency
  • Pulmonary Gas Exchange
  • Pulmonary Emphysema
  • Infant, Newborn
  • Hyaline Membrane Disease
  • Humans
  • High-Frequency Ventilation
  • High-Frequency Jet Ventilation
  • Extracorporeal Membrane Oxygenation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cotten, M., & Clark, R. H. (2001). The science of neonatal high-frequency ventilation. Respir Care Clin N Am, 7(4), 611–631. https://doi.org/10.1016/s1078-5337(05)70009-5
Cotten, M., and R. H. Clark. “The science of neonatal high-frequency ventilation.Respir Care Clin N Am 7, no. 4 (December 2001): 611–31. https://doi.org/10.1016/s1078-5337(05)70009-5.
Cotten M, Clark RH. The science of neonatal high-frequency ventilation. Respir Care Clin N Am. 2001 Dec;7(4):611–31.
Cotten, M., and R. H. Clark. “The science of neonatal high-frequency ventilation.Respir Care Clin N Am, vol. 7, no. 4, Dec. 2001, pp. 611–31. Pubmed, doi:10.1016/s1078-5337(05)70009-5.
Cotten M, Clark RH. The science of neonatal high-frequency ventilation. Respir Care Clin N Am. 2001 Dec;7(4):611–631.
Journal cover image

Published In

Respir Care Clin N Am

DOI

ISSN

1078-5337

Publication Date

December 2001

Volume

7

Issue

4

Start / End Page

611 / 631

Location

United States

Related Subject Headings

  • Respiratory System
  • Respiratory Insufficiency
  • Pulmonary Gas Exchange
  • Pulmonary Emphysema
  • Infant, Newborn
  • Hyaline Membrane Disease
  • Humans
  • High-Frequency Ventilation
  • High-Frequency Jet Ventilation
  • Extracorporeal Membrane Oxygenation