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Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor.

Publication ,  Journal Article
Collins, S
Published in: Life Sci
1993

The recent cloning of the beta 2-AR and other members of the adrenergic receptor family and related molecules has generated a flood of new information about the structure of this ubiquitous class of receptor molecules, and the ways in which their unique structures determine their function. Agonists interact with the receptor-binding pocket and somehow trigger conformational changes in the cytoplasmic portions of the receptor. These intracellular changes are then transmitted to the G-protein alpha-subunit. Phosphorylation of the receptor by several protein kinases and subsequent binding of additional cytosolic factors appear to be a major step in the control of receptor function. Changes in receptor gene expression which regulate receptor number and responsiveness provide another means to regulate transmembrance signalling. The realization that G-protein-coupled receptors are transcriptionally regulated by their own second messengers indicates that the parallels among the various members of this receptor family extend beyond their structural homologies, of 7 transmembrane segments and G-protein coupling, to include the genetic aspects of their regulation.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1993

Volume

52

Issue

26

Start / End Page

2083 / 2091

Location

Netherlands

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Protein Kinases
  • Pharmacology & Pharmacy
  • Humans
  • Gene Expression Regulation
  • GTP-Binding Proteins
  • Cyclic AMP
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Collins, S. (1993). Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor. Life Sci, 52(26), 2083–2091. https://doi.org/10.1016/0024-3205(93)90723-g
Collins, S. “Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor.Life Sci 52, no. 26 (1993): 2083–91. https://doi.org/10.1016/0024-3205(93)90723-g.
Collins, S. “Recent perspectives on the molecular structure and regulation of the beta 2-adrenoceptor.Life Sci, vol. 52, no. 26, 1993, pp. 2083–91. Pubmed, doi:10.1016/0024-3205(93)90723-g.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1993

Volume

52

Issue

26

Start / End Page

2083 / 2091

Location

Netherlands

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Protein Kinases
  • Pharmacology & Pharmacy
  • Humans
  • Gene Expression Regulation
  • GTP-Binding Proteins
  • Cyclic AMP
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology