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Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases.

Publication ,  Journal Article
Crawford, RD; Kalhagen, L; Wang, E; Telen, MJ
Published in: J Natl Med Assoc
2012

Kikuchi-Fugimoto's Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is most frequently seen in young women and has been associated with autoimmune disorders such as polymyositis and systemic lupus erythematosus. It is generally a self-limiting disease with recovery time ranging from weeks to months. A typical presentation of KFD includes painful cervical lymphadenopathy, usually consisting of unilateral involvement of the posterior cervical chain. To date, this condition has not been described in patients with sickle cell disease. We present 2 cases of KFD, 1 in a patient with sickle beta(o)-thalassemia (Sbeta(o)thal) and 1 in a patient with sickle cell anemia with hereditary persistence of fetal hemoglobin (HbS-HPFH). Both patients were young-adult African American females who presented with fever and unilateral tender cervical lymphadenopathy. Extensive infectious disease testing, including cultures and viral serologies, were all negative. Imaging was negative for abscesses. The first patient had a preceding history of benign carcinoid tumor and idiopathic thrombocytopenic purpura. The second patient had no history of autoimmune syndromes but was on hydroxyurea therapy at the time of her presentation; the first had never taken hydroxyurea. Treatment strategies included prednisone therapy in the first case and watchful monitoring in the second. Recovery time was approximately 2 months for each patient. Both developed thyroid disease subsequent to their episode of KFD. Currently, both patients are asymptomatic with no recurrence of KFD or active autoimmune disease.

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Published In

J Natl Med Assoc

DOI

ISSN

0027-9684

Publication Date

2012

Volume

104

Issue

9-10

Start / End Page

459 / 462

Location

United States

Related Subject Headings

  • Public Health
  • Neck
  • Lymph Nodes
  • Humans
  • Histiocytic Necrotizing Lymphadenitis
  • Female
  • Diagnosis, Differential
  • Biopsy
  • Anemia, Sickle Cell
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
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Crawford, R. D., Kalhagen, L., Wang, E., & Telen, M. J. (2012). Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases. J Natl Med Assoc, 104(9–10), 459–462. https://doi.org/10.1016/s0027-9684(15)30201-7
Crawford, Regina D., Lindsey Kalhagen, Endi Wang, and Marilyn J. Telen. “Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases.J Natl Med Assoc 104, no. 9–10 (2012): 459–62. https://doi.org/10.1016/s0027-9684(15)30201-7.
Crawford RD, Kalhagen L, Wang E, Telen MJ. Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases. J Natl Med Assoc. 2012;104(9–10):459–62.
Crawford, Regina D., et al. “Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases.J Natl Med Assoc, vol. 104, no. 9–10, 2012, pp. 459–62. Pubmed, doi:10.1016/s0027-9684(15)30201-7.
Crawford RD, Kalhagen L, Wang E, Telen MJ. Kikuchi-Fugimoto's disease in sickle cell disease: report of 2 cases. J Natl Med Assoc. 2012;104(9–10):459–462.
Journal cover image

Published In

J Natl Med Assoc

DOI

ISSN

0027-9684

Publication Date

2012

Volume

104

Issue

9-10

Start / End Page

459 / 462

Location

United States

Related Subject Headings

  • Public Health
  • Neck
  • Lymph Nodes
  • Humans
  • Histiocytic Necrotizing Lymphadenitis
  • Female
  • Diagnosis, Differential
  • Biopsy
  • Anemia, Sickle Cell
  • Adult