Common genetic variants on 5p14.1 associate with autism spectrum disorders.

Published

Journal Article

Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and neuropsychiatric disorders characterized by deficits in verbal communication, impairment of social interaction, and restricted and repetitive patterns of interests and behaviour. To identify common genetic risk factors underlying ASDs, here we present the results of genome-wide association studies on a cohort of 780 families (3,101 subjects) with affected children, and a second cohort of 1,204 affected subjects and 6,491 control subjects, all of whom were of European ancestry. Six single nucleotide polymorphisms between cadherin 10 (CDH10) and cadherin 9 (CDH9)-two genes encoding neuronal cell-adhesion molecules-revealed strong association signals, with the most significant SNP being rs4307059 (P = 3.4 x 10(-8), odds ratio = 1.19). These signals were replicated in two independent cohorts, with combined P values ranging from 7.4 x 10(-8) to 2.1 x 10(-10). Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.

Full Text

Duke Authors

Cited Authors

  • Wang, K; Zhang, H; Ma, D; Bucan, M; Glessner, JT; Abrahams, BS; Salyakina, D; Imielinski, M; Bradfield, JP; Sleiman, PMA; Kim, CE; Hou, C; Frackelton, E; Chiavacci, R; Takahashi, N; Sakurai, T; Rappaport, E; Lajonchere, CM; Munson, J; Estes, A; Korvatska, O; Piven, J; Sonnenblick, LI; Alvarez Retuerto, AI; Herman, EI; Dong, H; Hutman, T; Sigman, M; Ozonoff, S; Klin, A; Owley, T; Sweeney, JA; Brune, CW; Cantor, RM; Bernier, R; Gilbert, JR; Cuccaro, ML; McMahon, WM; Miller, J; State, MW; Wassink, TH; Coon, H; Levy, SE; Schultz, RT; Nurnberger, JI; Haines, JL; Sutcliffe, JS; Cook, EH; Minshew, NJ; Buxbaum, JD; Dawson, G; Grant, SFA; Geschwind, DH; Pericak-Vance, MA; Schellenberg, GD; Hakonarson, H

Published Date

  • May 2009

Published In

Volume / Issue

  • 459 / 7246

Start / End Page

  • 528 - 533

PubMed ID

  • 19404256

Pubmed Central ID

  • 19404256

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature07999

Language

  • eng