R-(-)-beta-phenyl-GABA is a full agonist at GABAB receptors in brain slices but a partial agonist in the ileum.

Published

Journal Article

R-(-)-beta-phenyl-GABA has been compared at GABAB receptors using cortical and ileal preparations. R-(-)-beta-phenyl-GABA (EC50 = 25 microM) was a less potent full agonist than R,S-(+/-)-baclofen (EC50 = 2.5 microM), in depressing CA1 population spikes of rat hippocampal slices, and 5 times less potent in attenuating the spontaneous discharges of rat neocortex. However, R-(-)-beta-phenyl-GABA (100-400 microM) was only a weak partial agonist in the ileum. All these actions were sensitive to CGP 35348 (3-aminopropyl-(P-diethoxymethyl)-phosphinic acid) and therefore mediated by GABAB receptors.

Full Text

Cited Authors

  • Ong, J; Kerr, DI; Doolette, DJ; Duke, RK; Mewett, KN; Allen, RD; Johnston, GA

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 233 / 1

Start / End Page

  • 169 - 172

PubMed ID

  • 8386087

Pubmed Central ID

  • 8386087

Electronic International Standard Serial Number (EISSN)

  • 1879-0712

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(93)90364-n

Language

  • eng