Efficacy of immune therapy in early experimental Naegleria fowleri meningitis.

Journal Article (Journal Article)

Naegleria fowleri meningoencephalitis is usually fatal in humans despite treatment. As a new approach, we tested intracisternal passive immune therapy in rabbits with amebic meningoencephalitis by using antinaegleria immune serum, an immunoglobulin G fraction, and a newly developed monoclonal antibody to N. fowleri. Both the immune serum and an immunoglobulin G fraction isolated from it by affinity chromatography provided a consistent, although temporary, protective effect, shown by prolongation of survival (P = 0.001). Multiple doses of immune serum further prolonged survival (P = 0.005). The protective effect of serum was retained after heating to 56 degrees C. We then developed a monoclonal antibody to N. fowleri which provided similar protection. Passive intracisternal antibody therapy might serve as an adjunctive component in the treatment of amebic meningoencephalitis.

Full Text

Duke Authors

Cited Authors

  • Lallinger, GJ; Reiner, SL; Cooke, DW; Toffaletti, DL; Perfect, JR; Granger, DL; Durack, DT

Published Date

  • May 1987

Published In

Volume / Issue

  • 55 / 5

Start / End Page

  • 1289 - 1293

PubMed ID

  • 3570464

Pubmed Central ID

  • PMC260503

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.55.5.1289-1293.1987


  • eng

Conference Location

  • United States